Author(s): Qinglin Yang and Qinqiang Long
The nuclear receptor peroxisome proliferator-activated receptor Ł?┐ (PPARŁ?┐) can transcriptionally regulate target genes. PPARŁ?┐ exerts essential regulatory functions in the heart, which requires constant energy supply. PPARŁ?┐ plays a key role in energy metabolism, controlling not only fatty acid (FA) and glucose oxidation, but also redox homeostasis, mitochondrial biogenesis, inflammation, and cardiomyocyte proliferation. PPARŁ?┐ signaling is impaired in the heart under various pathological conditions, such as pathological cardiac hypertrophy, myocardial ischemia/reperfusion, doxorubicin cardiotoxicity and diabetic cardiomyopathy. PPARŁ?┐ deficiency in the heart leads to cardiac dysfunction, myocardial lipid accumulation, cardiac hypertrophy/remodeling and heart failure. This article provides an up-today overview of this research area and discusses the role of PPARŁ?┐ in the heart in light of the complex mechanisms of its transcriptional regulation and its potential as a translatable therapeutic target for the treatment of cardiac disorders.