Author(s): Pallavi R. Devchand
One might imagine nuclear hormone receptor signaling systems as internal machines that continuously monitor every aspect of our lives. They intelligently adapt to our environments in ways we have yet to fully understand. When things go awry we describe it as maladaptive or dysregulated; and if persistent then over time we invoke a disease, disorder or simply aging. For centuries, humans have strived for health by using traditional aides like diet, exercise, sleep, temperature and drugs. In today’s medicine, we are creating external machines to intelligently monitor, interpret and sometimes mimic our internal biology. We want to understand what makes us tick, so we aim for machines that will consume personal and big data.