Author(s): Guillaume Holzer1 and Vincent Laudet2
The lamprey Petromyzon marinus belongs to the agnathans, the oldest vertebrate lineage from which jawed vertebrates diverged about 500 million years ago. Therefore, it holds a key phylogenetic position to understand the evolution of vertebrates. As in jawed vertebrates, two thyroid hormone receptors have been described in lamprey. These receptors, referred to as TR1 and TR2, behave as genuine TRs but are considered as an independent duplications when compared to the orthologs characterized in jawed vertebrates, TRα and TRβ. Here, we show that the lamprey genome contains two additional TR sequences. Their assignment to bona fide thyroid hormone receptors is supported by sequence alignments and phylogenetic reconstructions. This led us to revisit the phylogeny of thyroid hormone receptors and to detect an acceleration of their evolutionary rates at the basis of vertebrates. Our analysis therefore suggests that major evolutionary shifts occurred at the receptor level just when the modern synthesis of thyroid hormone was established during early vertebrate evolution.
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