Figure 5: Cumulative distribution function (CDF) curves for disorder analysis of NR A/B regions. The CDF curve reports the frequency of predicted ordered to disordered scores for amino acids along the length of the submitted protein sequence from PONDR VL-XT. Curves (derived at http://www.pondr.com/) for A/B regions of keratinocyte-expressed NR, calculated in the context of the full-length NR, are presented above. Peptide lengths predicted to be disordered have CDF lines with low cumulative disorder values (ranged 0.0–1.0) over much to most of the x-axis. NR A/B domains are presented for separate groups with (A) retinoid receptors (RARs and RXR), (B) liver X receptors (LXRs), (C) peroxisome proliferator activated receptors (PPARs) and (D) steroid receptors. The average CDF analysis for the 11 keratinocyte-expressed NR across the four panels is plotted in each panel as bolded red line. The order-disorder boundary (bold black line, upper right each panel) is from previously described datasets [102]. Ordered proteins plot above the boundary and disordered proteins below. Simons and colleagues have previously comprehensively reviewed amino-terminal domain ID [31,135] especially in regards to A/B allosteric interaction with other subdomains as highlighted for proteins in general by Berlow and coworkers [77]. Emphasis on steroid hormone receptor A/B regions can be found in [136,137].