|Figure 2: NR domain representation. Generic schematic of NR domains, not to scale.
Subdomains A/B – E/F are labeled with associated features above schematic: AF-1,
activating function 1; DBD, DNA binding domain; LBD, ligand binding domain; AF-2,
activating function 2. The extreme length diversity of the A/B region for 41 NR (8
amino acids as retrieved from Prosite) across the superfamily is indicated by a box-and-whisker
plot superimposed on an expanded generic A/B subregion below the full-length
receptor schematic. For the A/B regions lengths, the central two quartiles (plotted
cover a length range of 63-140 amino acids (to-scale region lengths indicated by 100
vertical marker lines). The first and fourth quartiles (right and left “whiskers",
extending from 8-62 and 141-201. Beyond the fourth quartile are 5 “outlier" lengths,
from the steroid NR3 group (blue circles ranging from 259-599).