|Figure 3: Allosteric coupling in nuclear receptors. A. Schematic representation of a NR-DNA-coregulator
complex with individual domains, coregulator and DNA response element labeled. Allosteric
has been demonstrated between B. ligand-and-DNA (gray); C. DNA and coregulator (gray);
D. ligand and
ligand (gray) in a NR dimer, and E. DNA and the NTD (gray).