|Figure 1: Canonical domain structure of a steroid receptor. A) SRs contain an amino-terminal
DNA-binding domain (DBD), hinge region and ligand binding domain (LBD). B) The LBD
(light blue) is comprised of 12 helices,
layered to form two functional sites: the ligand binding pocket, a hydrophobic cavity
where the steroid ligand (orange) binds;
and AF-2, the surface for coregulator (shown in green) interactions. The NTD contains
a ligand-independent activation function 1 domain.
(Crystal structure adapted from PDB 5UFS).