|Figure 1: PPARδ plays a crucial role in cardiac pathophysiology: PPARδ signaling is impaired
in the heart under various pathological conditions, such as pathological cardiac hypertrophy,
myocardial ischemia/reperfusion, doxorubicin cardiotoxicity and diabetic cardiomyopathy.
PPARδ deficiency in the heart leads to cardiac dysfunction, myocardial lipid accumulation,
cardiac hypertrophy/remodeling and heart failure.