|Figure 1: The GR family proteins. Human GR harbors three functional domains: N-terminal domain
(NTD), middle DNA-binding domain (DBD) and the C-terminal ligand-binding domain (LBD).
The DBD and LBD are linked by the hinge region (HR). Alternative splicing of the NR3C1
(gene encoding GR) gene generates the isoforms GRα, GRβ, GRγ, GR-A, and GR-P, which
differ in size and sequence of HR and/or LBD.