Figure 1: Cumulative distribution (solid curve) of NCBIestimated Hill slope coefficient (n
Hill ) values for those 746 hCAR activators, among 853 designated by NCBI [49] as
hCAR activators in HepG2 cells based on that analysis of in vitro luciferasereporter
assay results for >9,000 tested chemicals, which met additional activation criteria
described in Materials and Methods. The parameters (±1 standard error) of the corresponding
estimated lognormal distribution (dashed curve) are GM = 1.79 ± 0.00095 and GSD =
1.37 ± 0.0013, where GM and GSD denote geometric mean and geometric standard deviation,
respectively.

