Figure 1: Cumulative distribution (solid curve) of NCBI-estimated Hill slope coefficient (n Hill ) values for those 746 hCAR activators, among 853 designated by NCBI [49] as hCAR activators in HepG2 cells based on that analysis of in vitro luciferase-reporter assay results for >9,000 tested chemicals, which met additional activation criteria described in Materials and Methods. The parameters (±1 standard error) of the corresponding estimated lognormal distribution (dashed curve) are GM = 1.79 ± 0.00095 and GSD = 1.37 ± 0.0013, where GM and GSD denote geometric mean and geometric standard deviation, respectively.