Figure 2: Modelled seed structures derived from the GW590735 scaffold (i) the optimal GW590735 conformer in the non-cognate PPARγ_LBP (3VN2); (ii) GW5S1 and (iii) GW5S2 preserved the central O-linked spacer portion; (iv) GW5S3 conserved the terminal portions of the molecule (the dotted part was removed). Structures rendered in Accelrys® [18].