Table 2: Functions of Conserved Nuclear Receptors in Development.


Class D. melanogaster C. elegans M. musculus

1D E75 NHR-85 Rev-Erb α/β
molting, rhythms, metamorphosis, oogenesis molting, life cycle, female organogenesis rhythms
1E E78 SEX-1 (ortholog absent)
female organogenesis, oogenesis, gastrulation, metamorphosis female sex determination, female organogenesis
1F HR3 NHR-23 ROR α/β/γ
embryogenesis, metamorphosis, nervous system, trachea, cuticle, wings molting, life cycle, cuticle nervous system, immune system, rhythms, eyes
1H EcR (ortholog absent) LXR α/β
embryogenesis, metamorphosis, gut, male nervous system nervous system, immune system
1J HR96 DAF-12/NHR-8/-48 VDR/PXR/CAR
(none known) life cycle, longevity female organogenesis, immune system, bones
2A HNF4 superfamily HNF4 α/γ
(none known) excretory tube, germ-line, embryogenesis, hypodermis, muscle gastrulation, liver, nervous system
2B USP (ortholog absent) RXR α/β/γ
embryogenesis, metamorphosis, gut, male nervous system embryogenesis, heart, male spermatogenesis, neurogenesis, eyes, rhythms
2C HR78 NHR-41 TR2/TR4
molting, trachea, larval growth cuticle eyes, fetal growth, nervous system, embryogenesis, stem cells
2E TLL NHR-67 TLX
embryonic patterning, nervous system, eyes embryogenesis, nervous system, female organogenesis, cell migration, cell division nervous system, stem cells, eyes
2E DSF (ortholog absent) (ortholog absent)
nervous system
2E UNF FAX-1 PNR
nervous system, rhythms nervous system eyes
2E HR83 NHR-239 (ortholog absent)
(none known) (none known)
2F SVP UNC-55 COUP-TF α/β/EAR2
eyes, fat cells, heart nervous system embryogenesis, heart, vascular system, nervous system, bone, eyes
3B ERR (ortholog absent) ERR α/β/γ
spermatogenesis embryogenesis, heart, nervous system, kidney
4A HR38 NHR-6 NUR77/NURR1/NOR1
cuticle, morphogenesis, rhythms male organogenesis, cell division cell division, apoptosis, hematopoiesis, nervous system, liver, male organogenesis
5A FTZ-F1 NHR-25/-97/-119 SF-1/LRH-1
embryonic patterning, molting, morphogenesis, nervous system embryogenesis, female organogenesis, hypodermis, life cycle gonads, life cycle, adrenals, pituitary, nervous system, stem cells, gut, liver, pancreas
5B HR39 (ortholog absent) (ortholog absent)
female organogenesis
6A HR4 NHR-91 GCNF
embryogenesis, cuticle, metamorphosis life cycle embryogenesis, gametogenesis, nervous system, heart