Table 1: Conserved nuclear receptors.


Platyhelminthes Ecdysozoa Lophotrochozoa Echinodermata Chordata

Class S. mansoni D. melanogaster C. elegans C. gigas S. purpuratus H. sapiens
1A TRa/TRb NR1A THR TRα/β 1
1B NR1B RAR RAR α/β/γ 1
1C NR1C/CDa/CDb PPAR 1/2 PPAR α/β/γ 1
1D E75 NHR-85 NR1D RevErb Rev-Erb α/β 1
1E E78 E78 SEX-1 NR1E E78 a/b
1F HR3 1 NHR-23 NR1F ROR α/β/γ 1
1H EcR 1 ( Brugia EcR) NR1H FXR LXR α/β 1
FXR 1
1J HR96 HR96 DAF-12 1 NR1J a/b/g PXR 1
NHR-8/-48 VDR 1
CAR 1
2A HNF4 HNF4 superfamily NR2A HNF4 HNF4 α/γ 1
2B RXR1 USP ( Brugia USP) NR2B RXR RXR α/β/γ 1
RXR2
2C TR2/4 HR78 NHR-41 NR2CD NR2C TR2
TR2/4 TR4
2E TLL TLL NHR-67 NR2E1 TLX TLX
2E DSF DSF NR2E4 NR2E4
2E PNR UNF FAX-1 NR2E3 PNR PNR
2E HR83 NHR-239 NR2E5 NR2E5
2F COUP-TFI SVP UNC-55 NR2F COUP-TF COUP-TF α/β
COUP-TFII EAR2
3A NR3A ER α/β 1
3B ERR NR3B ERR ERR α/β/γ
4A NR4A5 HR38 NHR-6 NR4A NURR Nur77
Nurr1
NOR1
5A FTZ-F1a FTZ-F1 1 NHR-25/-97/ NR5A LRH-1 SF-1 1
-119 LRH-1 1
5B FTZ-F1b HR39 1 NR5B NR5B
6A HR4 1 NHR-91 ( Aplysia NR6A) GCNF GCNF
GRF

1NR with well-defined ligand.
Shaded rows identify the 18 NRs with broad phylogenetic conservation discussed in this review.