Table 3: Binding affinities of LXRα mutants for PPARα in the absence or presence of ligands.
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| Wild-type K d (nM) | H383E K d (nM) | E387Q K d (nM) | H390E K d (nM) | L414R K d (nM) | R415A K d (nM) | |
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| No ligand | 8 ± 2 | 7 ± 1 | 10 ± 2 | 27 ± 11 | 13 ± 5 | 14 ± 3 |
| T0901317 | 35 ± 6 | 13 ± 2 | 53 ± 9 | 9 ± 1 | 34 ± 6 | 23 ± 17 |
| 25HC | 16 ± 3 | 2 ± 0.5 | 49 ± 12 | 5 ± 1 | 2 ± 0.7 | 67 ± 13 |
| C16:0 FA | 104 ± 40 | 7 ± 1 | 27 ± 11 | 8 ± 1 | 2 ± 0.2 | 39 ± 22 |
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