Figure 3: Intrinsic quenching of (A) wild-type, (B) H383E, (C) E387Q, (D) H390E, (E) L414R, and (F) R415A LXRα aromatic amino acids by binding to T-0901317. Three independent experiments were performed for each analysis. (G) Docking of T-0901317 to the LXRα LBD shows the relative positioning of ligand in the ligand binding pocket of the receptor. LXRα LBD was extracted from the crystal structure of LXRα-RXRβ (PDB entry 1UHL).