|Figure 1: Interface of LXRα-RXRβ heterodimer showing the positioning of solvent accessible residues
(A) Contacts across the LXRα dimer interface. Location of amino acid residues H383,
E387, H390, L414, and R415 in helices 9 and 10 across the LXRα-RXRβ heterodimer as
proposed in the crystallographic structure (PDB 1UHL) (B) Schematic representation
of the LXRα domain structure showing single point mutations. All numbering is based
on LXRα isoform 1 (Uniport Q13133-1).