Table 2: Percent Identity comparisons of the DNA binding domain (DBD) and ligand binding domain (LBD) of orthologous human and F. heteroclitus nuclear receptors with Blastp.


Nuclear Receptor a DBD LBD Ligands b

SHP 51
DAX 51
THR α1-110 92 84 Thyroid hormones [ 114 ]
THR α2-10098 96 91
PPAR α1 86 85 Leukotriene B4,
1-palmityl-2-oleolyl-sn-glycerol-3-phosphocholine,
PPAR α2 86 73 Fatty acids [ 115 ]
Rev-Erb- β1-10090 94 83 Heme [ 114 ]
Rev-Erb- β2-10062 93 77
ROR α-9958 99 93
ROR α-369 91 75
ROR γ-9885 90 43
ROR γ-10005 90 47
FXR1-10028 96 72 5 β-bile acids [ 83 ]
FXR2-9861 84 35
VDR-A 93 79 1,25-OH vitamin D3, bile salts [ 116 , 117 ]
VDR-B 94 80
PXR 72 58 Xenobiotics, bile salts [ 73 , 80 ]
RXR β1-483 94 88 9-cis retinoic acid, rexinoids [ 114 , 118 ]
RXR β2-9867 90 79
RXR γ1-9885 94 95
RXR γ2-9880 94 95
PNR1-9949 93 74
PNR2-195 91 59
ESR1 96 66 17 β-estradiol [ 119 ]
ESR2 α-10024 96 68
ESR2 β-10026 96 65
ERR β-9910 100 76
ERR β-3 100 84
ERR γ-10140 97 94
ERR γ2-9925 91 81
GR-0 96 74 Cortisol [ 120 ]
GR2-10031 96 74
AR α-9941 65 59 Testosterone, 11-ketotestosterone, 17 α-methyltestosterone [ 121 ]
AR β-9884 91 70
NGF1B 99 69
Nurr77 93 66
NURR1a-9995 96 95
NURR1b-114 97 58
SF1a 72 58 Phosphatidylinositol, phosphatidylcholine [ 122 ]
FTZ-F2/SF1b-224 84 nd

aScaffold is often provided after the receptor to aid in determining the receptor in question.
bKnown or putative endogenous physiological ligands for fish (or human if fish unknown) are included for the receptors that show show high divergence from humans or have a duplicated receptor with potential neofunctionalization.