Figure 5: Oxidative stress in the kidney. The HFru administration caused an enhanced oxidative stress in the kidney, but GW501516 could not improve these changes. A: mRNA levels of antioxidant enzymes. B: SOD2 protein expression. C: CATALASE protein expression. D: GPX protein expression. E: GR protein expression. Data are presented as mean ± SD. *, **, *** and **** indicate P<0.05, P<0.01, P<0.001 and P<0.0001, respectively, compared with the SC group; †† indicates P<0.01 compared with the SC+GW group; $ indicates P<0.05 compared with the HFru group.