|Figure 8: We introduced in our dynamic model, all the possible permutations of the five-targeted
inhibitors PanERB inhibitor (1), CI1040 (MEK inhibitor) (2), PI103 (PI3K inhibitor)
(3), Perifosine (AKT inhibitor) (4), Nutlin-3 (MDM2 inhibitor) (5), in the presence
of the four mutations (and mutated pathways): APC (WNT pathway), KRAS (MAPK pathway),
SMAD4 (TGF-β pathway) and PI3K (PI3K pathway). In the ordinates, we show the increased
transcription rates of the complex described in Fig. 6. The numbers in the figures
indicate the combinations of inhibitors whose effects differ most from the median
value. Reproduced and slightly modify from .