Figure 7: We introduced in our dynamic model, all the possible permutations of the five mutations APC, KRAS, SMAD4, TP53, and PI3K (in the abscissae). In the ordinates, we show the increased transcription rates of the complex described in Fig. 6. Making = 1 the A.U. mRNA level for a physiologic situation, at 4-5 mutations and 20-30 A.U. mRNAs levels, we seem to cross the cell-cycle restriction point. Reproduced and slightly modify from [29].