Table 1: Role of PXR activation in specific cancer types.


Type of cancer Characteristics of PXR activation (References)

Prostate cancer Increases tumor progression and resistance to the chemotherapy drugs [ 51 , 52 ]
Breast cancer Increases cell proliferation [ 59 ] and resistance to the chemotherapeutics [ 60 , 61 , 62 ]
Inhibits cell proliferation and induces apoptosis [ 45 ]
Ovarian cancer Induces cell proliferation, tumor growth and resistance to the chemotherapeutics [ 40 ]
Endometrial cancer Decreases cell growth inhibition and apoptosis induced by the chemotherapy drugs [ 41 ]
Cervical cancer Inhibits cell proliferation and tumor growth [ 39 ]
Colon cancer Increases cell growth, invasion and metastasis [ 42 ]. PXR activation also increases oxidative stress and anti-apoptotic activity, and decreases pro-apoptotic activity [ 44 , 46 ]. Moreover, PXR activation enhances resistance to the chemotherapy drugs [ 4 , 5 , 48 , 67 , 68 ]
Decreases inflammation, cell proliferation and tumor growth [ 65 , 66 ].
Liver cancer Promotes tumor growth and chemo-resistance [ 35 , 76 ]
Gastric cancer Contributes to chemo-resistance [ 81 ]
Pancreatic ductal adenocarcinoma Promotes chemo-resistance [ 82 ]
Hematologic cancers Inhibits development of B cell lymphoma [ 71 ] and sensitizes chronic myeloid leukemia cells to the chemotherapeutics [ 28 ]