Table 6: PPAR Corepressors.


Corepressor Receptor Condition Outcome

NCoR/SMRT PPAR α – In absence of ligands SUMOlyaltiom leads to recruitmmrnt of NCoR, but not SMRT – downregulation of transcriptional activity
PPAR β/ δ – Dependent of coactivator/Corepressor ratio – decreased exercise endurance
PPAR γ – In absence of ligand – Binding increases by SUMOlylation of PPAR γ – inhibition of adipogenesis, increase of inflammation, decreased insulin activity
HMGA 1 PPAR γ – Ligand-dependent – loss of vascular protection
TRB3 PPAR γ – inhibition of adipocyte differentiation
LCoR PPAR γ – Ligand-dependent – Acts as depressor at low levels – inhibition of splenic macrophages
RIP 140 PPAR α PPAR β/ δ PPAR γ – ligand dependent activator and repressor depending on the relative level of RTP 140 in comparison to other cofactors – Inhibition of mRNA expression of PPAR α and PPAR β/ δ and their target genes. – Suppression of BAT-specific genes in WAT
TNIP 1 PPAR α PPAR β/ δ PPAR γ – Ligand dependent – partial repression
TAZ PPAR γ – Ligand dependent – attenuation of adipogenic gene expression and adipocyte differentiation
CoPR 1 PPARs – Ligand dependent – Partial repression
CoPR 2 PPARs – Ligand dependent – Partial repression
Brd 2 PPAR γ – Inhibition of adipogenesis