Table 5: PPAR Coactivators.


Coactivator Receptor Condition Outcome

PGC1 α PPAR α – ligand dependent – Stimulation of FA oxidation, promotion of mito biogenesis
PPAR β/ δ – ligand dependent and independent – Mito FA oxidation
PPAR γ – ligand dependent and independent Mediation of adaptive thermogenesis and fiber type switching of skeletal muscle
PGC1 β PPAR α – ligand independent – inhibition of PPAR α transcriptional activity
PPAR β/ δ – in cooperation with PGC1 α – maximize mito FA oxidation
SRC 1 PPAR α – ligand independent
PPAR γ – ligand dependent – promotion of energy expenditure
SRC 2 PPAR γ – ligand dependent – repression of energy expenditure, promotion of adipocyte differentiation
SRC 3 PPAR α – ligand independent
PPAR γ – ligand dependent – promotion of adipocyte differentiation
CBP/P300 PPAR α – ligand dependent – regulation of brown fat UCP-1
PPAR β/ δ – ligand depentant Fat-burning stimulation
PPAR γ – ligand dependent and independent
Med 1 PPAR α – ligand dependent – hepatic cell and peroxisome proliferation
PPAR γ – ligand dependent – no effect on PPAR γ transcriptional activity
Med 14 PPAR γ – ligand independent – fatty acid storage and adipogenesis
PRIP PPAR α – Ligand dependent – no effect on PPAR α transcriptional activity
PPAR γ – ligand dependent – adipogenesis
PRIC 285 PPAR α PPAR β/ δ PPAR γ – ligand dependent Moderate stimulation of transcription
PRIC 320 PPAR α PPAR γ – ligand dependent – lesser degree than with PPAR α
PRIC 295 PPAR α PPAR γ – ligand dependent – ligand dependent Enhance transactivation Enhance transactivation
SWI/SNF PPAR α – FA oxidation and hepatic lipid metabolism
PPAR γ – adipogenesis
BAF60 a PPAR α – PGC1 α dependent – Mitochondrial and peroxisomal – β-oxidation
BAF60 C PPAR γ – ligand independent Enhance transcriptional activity
PIMT PPAR γ
CARMI PPAR γ – adipocyte differentiation
NcoA4/ARA70 PPAR α PPAR γ – in absence of RXR – in presence of RXR – ligand independent – activation – repression – antiinflammatory effect
PRDM 16 PPAR γ – activation of BAT selective genes and suppression of WAT selective genes
TLE3 PPAR γ – adipocyte differentiation blocks interaction with PRDM 16, promotes lipid storage, inhibits thermogenic gene expression
CCPG PPAR γ – ligand independent – adipogenesis
TRIP3 PPAR γ – ligand dependent – adipogenesis