Table 4: PPAR Domain Functions.


N- terminal DNA Binding domain Hinge region Carboxyl terminal

transactivating function (AF–1) Zinc finger binding motifs Nuclear localization signals Ligand – independent Largest domain
Phosphorylalion sites Recognize PPREs Phosphorylation sites required for dimerization (PPAR α) Contains LBD
Determines subtype-selective gene expression Phosphorylation sites (PPAR α & PPAR γ) Dimerization Interacts with HSP90 (PPAR α more than PPAR β/ δ or PPAR γ) Interacts with HSP90 (PPAR α more than PPAR β/ δ or PPAR γ)
Ligand-induced stabilization (PPAR β/ δ) Ribosomal protein rpL 11 inhibits activity Coactivator binding of PPAR α AF-2; for cofactors recruitment
Modulates binding to DNA Dimerization
Docking domain for coactivators Contains nuclear localization sequence