Table 3: Species Differences in Hepatic Peroxisomal β-Oxidation in Response to PPAR α Activators in vitro a.


Drug Rat Rhesus Monkey

Bezafibrate b 7.99 1.39
Ciprofibrate b 9.95 1.77
LY 17,1883 c 5.44 1.44

aFold increase in hepatic peroxisomal β-oxidation activity; b200 μM for 3 days; c100 μM for 3 days [ 300 ].