Figure 2: Figure 2. RORγt-dependent induction of Th17 differentiation and Th17-associated genes. In Th0 cells, IRF4 and BATF are bound to chromatin near Th17-associated genes, but the loci are transcriptionally silent. Upon exposure to cytokines, such as IL-6, STAT-3 becomes phosphorylated and transfers to the nucleus, where it binds DNA near IRF4 and BATF and induces Rorc transcription. RORγt can then join the IRF4/BATF/STAT3 transcription factor complex and induce expression of Th17-associated genes, such as Il17 and Il23r.