Table 5: Summary of somatic mutation bootstrapping results comparing the protein coding sequence mutation frequencies (mutations/coding base pair) of members of 13 TF families, including NRs, across six different tumor types relative to the protein coding genome. Shown is the observed mutation frequency for each TF family (TF AVG), including NRs, as well as the mean value of the protein coding genome background (TCGA AVG) for each respective cancer, as well as the bootstrapping results comparing the two. Significantly distorted mutation frequencies are highlighted in yellow (P< 0.05). Note that coding sequences of NRs not commonly mutated relative to the background protein coding genome. Also, the most commonly mutated member of each TF family is listed for each respective cancer, along with its respective mutation frequency and how it relates to the background mutation frequency (mutation ratio).

table3