Table 3: Summary of gene expression bootstrapping results comparing the average tumor/normal relative expression (% of tumors displaying overexpression (Z-score 2) and % of tumors displaying underexpression (Z-score -2)) of detectable members of 13 TF families, including NRs, across six different tumor types, relative to the background transcriptome. Shown is the observed value for each TF family (TF AVG), including NRs, as well as the mean value of the transcriptome background (TCGA AVG) for each respective cancer, as well as the bootstrapping results comparing the two. Significantly distorted expression patterns are highlighted in yellow (P< 0.05). Note that NRs are less commonly upregulated, and more commonly downregulated, than would be predicted by chance across all six tumor types.

table3