Figure 4: Nuclear Receptors are not common targets of somatic mutation in cancer. (A) Heatmap depicting non-synonymous mutations found in protein coding regions for all 48 NRs (rows) in 977 primary BRCA samples (columns). Observed mutations are depicted in blue. (B) Bootstrapping results comparing the observed mutation frequency (mutations/protein coding base pair) for NRs relative to the background protein coding genome in BRCA. Note that NRs are not significantly mutated more or less than is predicted by chance.