Figure 2: Nuclear Receptors are downregulated in cancer. (A) Heatmap depicting the relative
expression of all 42 NRs (rows) detectable in 1095 BRCA samples (columns) relative
to the expression of NRs observed in a pool of 113 matched normal samples. Tumors
with relative expression (Zscore) ≥ +/ 2 are considered significantly upregulated
(red) or downregulated (green), respectively. (B) Bootstrapping results comparing
the observed mean % of tumors with significantly disrupted expression for NRs relative
to the background transcriptome in BRCA. Note that NRs are significantly upregulated
less than is predicted by chance (P = 0.00065) and significantly downregulated more
than is predicted by chance (P = 0.00179). (C) PanCancer summary of NR expression
patterns. Relative expression scores were determined by summing the Zscores for a
given gene in a given cancer and dividing by the square root of the number of tumors
available for that tumor type.

