Table 1: Effect of cuprizone treatment on the expression of nuclear receptors in the murine corpus callosum (Affimetrix gene chip).


probe set gene control 2 w Cu 5 w Cu 9 w Cu 13 w Cu

10381082 RAR α (NR1B1) present (7.55) 0.86 0.85 0.67 0.76
10417713 RAR β (NR1B2) high (9.34) 0.91 1.14 0.74 0.79
10432972 RAR γ (NR1B3) present (7.27) 1.01 1.17 1.06 1.11
10470446 RXR α (NR2B1) present (7.87) 1.01 0.95 0.97 0.93
10444137 RXR β (NR2B2) present (7.85) 1.14 1.51 1.41 1.34
10351430 RXR γ (NR2B3) high (8,75) 0.78 0.94 0.60 0.60
10562847 LXR α (NR1H2) high (8.77) 1.36 1.26 1.28 1.26
10484987 LXR β (NR1H3) present (6.95) 1.05 1.12 1.13 1.01
10425987 PPAR α (NR1C1) low (6.68) 1.00 0.94 0.89 0.96
10443332 PPAR β/ δ (NR1C2) high (8.93) 0.93 0.56 0.55 0.60
10540897 PPAR γ (NR1C3) present (7.84) 1.13 0.59 0.83 0.74
10586700 ROR α (NR1F1) high (8.80) 1.06 1.10 1.11 1.16
10466587 ROR β (NR1F2) high (8.13) 1.19 1.63 2.25 1,72
10494023 ROR γ (NR1F3) present (7.45) 1.29 0.79 0.85 0.94
10585438 CRABP-I present (8.31) 0.95 0.73 0.61 0.62
10493108 CRABP-II low (6.41) 1.12 1.03 1.07 1.06
10585699 FABP-5 high (8.57) 0.76 1.77 1.62 1.58
10363224 FABP-7 low (6.95) 1.27 3.32 2.05 1.38

Expression after 2, 5, 9, and 13 weeks cuprizone treatment are expressed as fractions of the levels of non-treated controls. Changes of more than 0.5 are highlighted in bold font.