|Figure 2: Examples of immunohistochemical staining illustrate the effect of cuprizone and NR
agonists on oligodendrocytes. Shown are sections of the caudal Cc following treatments;
(a) control condition, normal chow; (b) after three weeks of cuprizone feeding; (c)
combined cuprizone feeding with injection of all-trans RA; (d) combined treatment
of cuprizone with 9-cis RA; and (e) combined treatment of cuprizone with T0901317.
Oligodendrocytes were marked with an antibody against adenomatous polyposis coli (APC).
Scale bar 100 µm in panel e is valid for all photographs.