Figure 2: Examples of immunohistochemical staining illustrate the effect of cuprizone and NR agonists on oligodendrocytes. Shown are sections of the caudal Cc following treatments; (a) control condition, normal chow; (b) after three weeks of cuprizone feeding; (c) combined cuprizone feeding with injection of all-trans RA; (d) combined treatment of cuprizone with 9-cis RA; and (e) combined treatment of cuprizone with T0901317. Oligodendrocytes were marked with an antibody against adenomatous polyposis coli (APC). Scale bar 100 ┬Ám in panel e is valid for all photographs.