Table 3: Effect of dexamethasone on liver oxidative stress indices of cyclophosphamide treated rats.


Treatments SOD (U/mg protein) CAT (U/mg protein) GSH (µmole /mg protein) GPx (U/mg protein) MDA (nmol /mg protein)

Control 20.0 ± 2.00a 31.9 ± 2.70a 15.0 ± 1.00a 15.4 ± 1.33a 0.15 ± 0.07a
DEXA 21.1 ± 2.22a 33.7 ± 2.42a 16.1 ± 1.27a 15.9 ± 2.21a 0.13 ± 0.09a
CP 8.70 ± 0.63c 12.0 ± 1.20c 4.10 ± 0.20c 4.13 ± 0.32c 0.89 ± 0.01c
CP+DEXA (Post) 11.8 ± 0.57d π 17.1 ± 2.01d π 6.51 ± 0.19d π 6.00 ± 0.25d π 0.55 ± 0.06d π
CP+DEXA (Cotr) 14.9 ± 1.33e # 22.8 ± 2.42e # 9.75 ± 0.17e # 9.32 ± 0.06e # 0.32 ± 0.07e #
DEXA+CP (Pret) 19.4 ± 1.27f * 30.7 ± 2.31f * 14.6 ± 1.54f * 13.0 ± 1.32f * 0.20 ± 0.04f *

Data presented as mean ± SEM, n = 6, Cyclophosphamide, DEXA: Dexamethasone Post: Post-treatment,Cotr: Co-treatment, Pret: Pre-treatment, SOD: Superoxide dismutase, MDA: Malondialdehyde, GSH: Glutathione, GPx: Glutathione peroxidase, CAT: Catalase. Values with different alphabets down the column differ at p < 0.05, π p < 0.05 in comparison to CP, #p < 0.01 in comparison to CP, *p < 0.001 in comparison to CP