Table 2: Effect of dexamethosone on liver tissue biochemical indices of cyclophosphamide-treated rats.


Group AST (U/L) ALT (U/L) ALP (U/L) GGT (U/L) LDH (U/L)

Control 200.3 ± 14.7a 227.7 ± 16.2a 191.9 ± 15.0a 30.3 ± 2.12a 175.1 ± 13.7a
DEXA 198.1 ± 16.3a 210.6 ± 19.0a 185.4 ± 17.5a 28.7 ± 2.00a 160.7 ± 10.8a
CP 891.3 ± 23.2c 811.1 ± 24.8c 760.8 ± 22.7 c 107.9 ± 10.3c 780.3 ± 20.2 c
CP+DEXA (Post) 650.6 ± 17.7d π 610.8 ± 28.5d π 510.6 ± 20.1d π 70.8 ± 6.33d π 560.8 ± 16.1d π
CP+DEXA(Cotr) 530.7 ± 19.1e # 500.6 ± 17.1e # 370.7 ± 14.3 e # 50.4 ± 4.32 e # 400.1 ± 15.0 e #
DEXA+CP(Pret) 390.1 ± 18.9f* 370.5 ± 13.8f * 240.1 ± 12.0 f* 33.5 ± 2.37 f * 251.4 ± 11.2 f *

Data presented as mean ± SEM, n = 6, CP: Cyclophosphamide, DEXA: Dexamethasone, Post: Post-treatment, Cotr: Co-treatment, Pret: Pre-treatment, AST: Aspartate aminotransferase, GGT: Gamma-glutamyltransferase, ALT: Alanine aminotransferase, ALP: Alkaline phosphatise, LDH: Lactate dehydrogenase. Values with different alphabets down the column differ at p < 0.05, π p < 0.05 in comparison to CP, #p < 0.01 in comparison to CP, *p < 0.001 in comparison to CP