Table 3: Effects of stevia and/or glimepiride on kidney function test of diabetic rats.


Regimens Kidney function test (mg/dl)
Groups Treatment Dose and duration (mg/kg) Urea Creatinine

1 Normal control (non-diabetic) Saline Saline Equal volumes single I.P Equal volumes orally for 3weeks 39.1 ± 1.8 0.8 ± 0.04
2 Diabetic control STZ + NA Vehicle(Saline /Tween) Equal volumes single I.P Equal volumes orally for 3weeks 60.6 ± 4.3 1.3 ± 0.07
3 Stevia extract STZ + NA Stevia extract STZ 55 mg/kg single I.P + NA 230 mg/kg 300 mg/kg stevia orally for3weeks 48.4 ± 2.7* 0.87 ± 0.04***
4 Glimepiride STZ + NA Glimepiride STZ 55 mg/kg single I.P + NA 230 mg/kg 1 mg/kg glimepiride orally for 3weeks 43 ± 1.7*** 0.8 ± 0.02***
5 Glimepiride + Stevia extract STZ + NA Glimepiride + Stevia extract -STZ 55 mg/kg single I.P + NA 230 mg/kg (1 mg/kg glimepiride + 300 mg/kg stevia) orally for 3weeks 40.5 ± 2.6*** 0.72 ± 0.02***

Values represent mean ± S.E.M.
*Significant difference at P < 0.05 vs. diabetic value.
** Significant difference at P < 0.01 vs. diabetic value.
*** Significant difference at P < 0.001 vs. diabetic value.
N.B: There is no difference between different control vehicles.