Table 2: Influence of stevia and/or glimepiride on liver function test of diabetic rats.


Regimens Liver function test

Groups Treatment Dose and duration (mg/kg) ALT(U/I) AST(U/I) Total protein conc. (mg/dl)

1 Control (non-diabetic) Saline Saline Equal volumes single I.P Equal volumes orally for 3weeks 26.7 ± 2.8 18.7 ± 2.3 7.7 ± 0.2
2 Diabetic control STZ + NA Vehicle(Saline /Tween) Equal volumes single I.P Equal volumes orally for 3weeks 62.3 ± 4.2 51 ± 5.3 9.4 ± 0.4
3 Stevia extract STZ + NA Stevia extract STZ 55 mg/kg single I.P + NA 230 mg/kg 300 mg/kg stevia orally for 3weeks 32.6 ± 4.6*** 31.7 ± 3.7** 8.6 ± 0.5
4 Glimepiride STZ + NA Glimepiride STZ 55 mg/kg single I.P + NA 230 mg/kg 1 mg/kg glimepiride orally for 3weeks 28.5 ± 2.4*** 23.5 ± 0.9*** 7.8 ± 0.1**
5 Glimepiride + Stevia extract STZ + NA Glimepiride + Stevia extract -STZ 55 mg/kg single I.P + NA 230 mg/kg (1 mg/kg glimepiride + 300 mg/kg stevia) orally for 3weeks 22.3 ± 1.7*** 18.1 ± 1.2*** 7.2 ± 0.2***

Values represent mean ± S.E.M.
*Significant difference at P < 0.05 vs. diabetic value.
** Significant difference at P < 0.01 vs. diabetic value.
*** Significant difference at P < 0.001 vs. diabetic value.
N.B: There is no difference between different control vehicles.