Table 1: Influence of stevia and/or glimepiride on blood glucose levels of diabetic rats.


Regimens Blood glucose levels ( mg/dl) at time intervals
Groups Treatment Dose and duration (mg/kg) Day 0 Day 5 Day 10 Day 15 Day 21

1 Control (non-diabetic) Saline Saline Equal volumes single I.P Equal volumes orally for 3weeks 130.8 ± 5.4 126.7 ± 6.3 121.7 ± 5 126.7 ± 4.4 116.7 ± 5.7
2 Diabetic control STZ + NA Vehicle (Saline/Tween) Equal volumes single I.P Equal volumes orally for 3weeks 456.7 ± 23.3 440 ± 23.1 406.7 ± 22 393.3 ± 20.3 386.7 ± 18.5
3 Stevia extract STZ + NA Stevia extract STZ 55 mg/kg single I.P + NA 230 mg/kg 300 mg/kg stevia orally for 3weeks 451.7 ± 4.4 391.7 ± 4.4 350.0 ± 17.3 276.7 ± 8.8 205 ± 14.4**
4 Glimepiride STZ + NA Glimepiride STZ 55 mg/kg single I.P + NA 230 mg/kg 1 mg/kg glimepiride orally for 3weeks 465 ± 39.6 414.5 ± 28.8 346.8 ± 24.8 283.8 ± 13 221.3 ± 15**
5 Glimepiride + Stevia extract STZ + NA Glimepiride + Stevia extract STZ 55 mg/kg single I.P + NA 230 mg/kg (1 mg/kg glimepiride + 300 mg/kg stevia) orally for 3weeks 475 ± 37.5 352.5 ± 20.5 237.5 ± 17.5 170.5 ± 9.5 132.5 ± 11.1***

Values represent mean ± S.E.M.
** Significant difference at P < 0.01 vs. initial diabetic value
*** Significant difference at P < 0.001 vs. initial diabetic value.
N.B: There is no difference between different control vehicles.