Table 2: Activities of melatonin and alpha lipoic acid on liver tissue biochemical indexes of methotrexate-treated rats.


Treatment ALT(U/L) AST(U/L) ALP(U/L) GGT(U/L) LDH (U/L)

Control 200.5±12.5 bcd 255.6±10.1 bcde 190.1±8.43 bcd 160.0±9.54 bcd 30.8±2.00 bcde
MT 197.0±11.6 bcd 245.5±12.3 bcde 185.6±9.00 bcd 152.2±8.11 bcd 29.0±2.15 bcde
ALA 195.7±11.7 bcd 250.3±10.7 bcde 189.4±8.01 bcd 150.6±9.50 bcd 30.0±2.43 bcde
MT+ ALA 190.8±10.9 bcd 235.0±11.6 bcde 179.7±9.54 bcd 147.4±10.2 bcd 29.5±2.00 bcde
MTX 785.3±15.4 acde 893.6±14.0 acde 699.3±15.1 acde 690.5±18.1 acde 95.9±6.14 acde
MT +MTX 401.7±12.3 a b e 525.2±10.2 abde 373.1±10.4 a b e 339.3±11.8 abe 65.3±3.62 abde
ALA +MTX 417.5±10.7 abe 421.5±11.5 abce 380.4±11.6 abe 350.1±12.1 abe 50. 1±4.41 abce
MT+ALA+MTX 215.4±10.5 bcd 320.6±12.6 abcd 200.0±10.2 bcd 170.9±10.5 bcd 37.0±2.32 abcd

MTX: Methotrexate, MT: Melatonin, ALA: Alpha lipoic Acid, n=6, Data are expressed as Mean± SEM, a Difference at p<0.05 when compared to control, b Difference at p<0.05 when compared MTX, c Difference at p<0.05 when compared MT+MTX, d Difference at p<0.05 when compared ALA+MTX, e Difference at p<0.05 when compared MT+ALA+MTX