Table 2: Biochemical tests in Brain hemolysate study (mean ± SD) of different groups


Parameters Groups (n. 8 rats in each group)

1 Control 2 Reserpine 3 ML+R 4 MH+R 5 S+R 6 S+ML+R 7 S+MH+R
Dopamine (pg/ml) (mean ± SD) 115 ± 16.76 * 62.85 ± 10.3 * 75 ± 16.28 * 84.58 ± 10.48 * 71.75 ± 17.1 * 88.33 ± 13.57 * 85.68 ± 16
MDA (nmol/ml) (mean ± SD) 13.12 ± 3.09 * 82.85 ± 17.68 *# 44.02 ± 9.61 *# 37.93 ± 5.703 *# 49.1 ± 5.359 #@ $% 19.4 ± 3.351 #@ $% 0.33 ± 3.59
GSH (nmol/ml) (mean ± SD) 61.18 ± 4.44 * 26.22 ± 5.31 *# 41.9 ± 5.319 *# 42.68 ± 3.955 *# 39.5 ± 7.227 #@ $% 52.72 ± 6.206 # $% 52.13 ± 4.06
α Synuclein (mean ± SD) 1.01 ± 0.014 * 4.95 ± 0.21 *# 2.58 ± 0.679 # 2.18 ± 0.18 *# 3.085 ± 0.02 # 1.85 ± 0.49 # 2.1 ± 0.424

Data are presented as mean ± SD. *,#,@, $,% : Statistically significant compared to corresponding value in control, reserpine, Low dose Metformin + Reserpine group, High dose Metformin + Reserpine, Selegiline + Reserpine group respectively. Level of significance is set at P value < 0.05. R: Reserpine, ML: Metformin low dose, MH: Metformin high dose, S: Selegiline