Table 4: Effect of 21-day chronomodulated nifedipine administration serum renal markers in glimepiride-treated hyperglycaemic rats.


Groups Mg 2+ (mg/dl) Cholesterol (mg/dl) Triglyceride (mg/dl)

Non-diabetic control 2.38 ± 0.12 65.21 ± 12.55 5.00
Diabetic control 1.08 ± 0.21* 187.97 ± 6.77** 18.20*
Glimepiride 2000 hrs 1.51 ± 0.13 158.74 ± 8.74* 17.00
Glim2000hrs+Nife2000hrs 1.65 ± 0.26 145.12 ± 5.86* 18.20
Glim2000hrs+Nife0800hrs 2.35 ± 0.16 # 63.68 ± 5.57 ## 6.60 #

Data are mean ± SEM and mean rank (Triglyceride) * = p≤ 0.05 compared to non-diabetic control, ** = p≤ 0.01 compared to non-diabetic control, # = p≤ 0.05 compared to diabetic control, ## = p≤ 0.01 compared to diabetic controlone way ANOVA followed by Bonferoni post hoc test for Mg 2+ and Cholesterol, Kruskal Wallis and Dunn-Bonferoni post hoc test for triglyceride, n = 5-8,Glim2000hrs+Nife0800hrs = treated with glimepiride at 2000 hrs and nifedipine at 0800 hrs; Glim2000hrs+Nife2000hrs = treated with glimepiride at 2000 hrs and nifedipine at 2000 hrs