Table 3: Effect of 21-day chronomodulated nifedipine administration on thermal hyperalgesia in glimepiride-treated hyperglycaemic rats.


Groups Reaction time (s)

Day 7 Day 14 Day 21
Non-diabetic control 7.89 ± 0.42 7.75 ± 0.52 7.75 ± 0.45
Diabetic control 5.28 ± 0.71 ## 3.42 ± 0.36* ## 1.71 ± 0.35** ##
Glimepiride 2000 hrs 3.42 ± 0.31 ## 3.28 ± 0.35 ## 2.42 ± 0.29 ##
Glim2000hrs+Nife2000hrs 3.80 ± 0.91 ## 3.40 ± 0.40 2.40 ± 0.40 ##
Glim2000hrs+Nife0800hrs 3.00 ± 0.31 ## 5.20 ± 0.80* a 5.60 ± 0.50* a

Data are mean ± SEM, * = p≤ 0.05 compared to day seven, ** = p≤ 0.01 compared to day seven, ## = p≤ 0.01 compared to non-diabetic control a = p≤ 0.05 compared to diabetic control, split plot ANOVA and Bonferoni post hoc test, n = 5-8,Glim2000hrs+Nife0800hrs = treated with glimepiride at 2000 hrs and nifedipine at 0800 hrs; Glim2000hrs+Nife2000hrs = treated with glimepiride at 2000 hrs and nifedipine at 2000 hrs