Table 2: Effect of 21-day chronomodulated nifedipine administration on mechanical hyperalgesia in glimepiride-treated hyperglycaemic rats.


Groups Force (g)

Day 7 Day 14 Day 21
Non-diabetic control 130.87 ± 3.52 121.87 ± 7.88 119.87 ± 6.89
Diabetic control 77.14 ± 2.51 ## 42.71 ± 3.49** # 32.28 ± 0.89** ##
Glimepiride 2000 hrs 67.57 ± 5.85 ## 53.42 ± 5.88 # 48.42 ± 3.47 ##
Glim2000hrs+Nife2000hrs 89.00 ± 5.24 ## 71.80 ± 8.81 58.20 ± 4.40* ##
Glim2000hrs+Nife0800hrs 65.40 ± 9.96 ## 82.40 ± 3.68* a 98.20 ± 1.22* ## a

Data are mean ± SEM, * = p≤ 0.05 compared to day seven, ** = p≤ 0.01 compared to day seven, # = p≤ 0.05 compared to non-diabetic control, ## = p≤ 0.01 compared to non-diabetic control a = p≤ 0.05 compared to diabetic control, split plot ANOVA and Bonferoni post hoc test, n = 5-8,Glim2000hrs+Nife0800hrs = treated with glimepiride at 2000 hrs and nifedipine at 0800 hrs; Glim2000hrs+Nife2000hrs = treated with glimepiride at 2000 hrs and nifedipine at 2000 hrs