Table 1: Effect of 21-day chronomodulated nifedipine administration on body weight in glimepiride-treated hyperglycaemic rats.


Groups Weight (g)

Day 0 Day 7 Day 14 Day 21
Non-diabetic control 118.60 ± 2.11 132.20 ± 3.91* 140.20 ± 4.23** 152.60 ± 5.74**
Diabetic control 115.20 ± 5.30 123.20 ± 5.30 114.40 ± 4.60 a 114.00 ± 4.24 a
Glimepiride 2000 hrs 113.20 ± 3.70 118.80 ± 4.35 126.00 ± 6.32* # 130.20 ± 5.1* #
Glim2000hrs+Nife2000hrs 124.60 ± 3.55 129.00 ± 3.80 130.80 ± 4.18 132.40 ± 5.71
Glim2000hrs+Nife0800hrs 120.60 ± 3.66 129.60 ± 5.85* 140.00 ± 4.56** # 129.89 ± 7.95** #

Data are mean ± SEM, * = p≤ 0.05 compared to day zero, ** = p≤ 0.01 compared to day zero, a = p≤ 0.05 compared to non-diabetic control, # = p≤ 0.05 compared to diabetic control, split plot ANOVA and Bonferoni post hoc test, n = 5-8, Glim2000hrs+Nife0800hrs = treated with glimepiride at 2000 hrs and nifedipine at 0800 hrs; Glim2000hrs+Nife2000hrs = treated with glimepiride at 2000 hrs and nifedipine at 2000 hrs