Figure 1: Effect of 21-day chronomodulated nifedipine administration on FBG in glimepiride-treated hyperglycaemic rats. Data are mean ± SEM, b = p≤ 0.01 compared to non-diabetic control ** = p≤ 0.01 compared to day zero## = p≤ 0.01 compared to diabetic control, split plot ANOVA and Bonferoni post hoc test, n = 5-8, Glim2000hrs+Nife0800hrs = treated with glimepiride at 2000 hrs and nifedipine at 0800 hrs; Glim2000hrs+Nife2000hrs = treated with glimepiride at 2000 hrs and nifedipine at 2000 hrs.