Table 4: Effect of 4-aminopyridine (0.5, 1, 2, and 4 mg/kg/s.c) (Kv channel blocker) with diclofenac (10 mg/kg/i.p.) in the maximal electroshock seizure test in mice.


Diclofenac (10mg/kg,i.p)+4-aminopyridine(0.5,1,2 mg/kg/s.c) Percentage of convulsion in (MES) model

0.5 mg/kg/s.c 66.7%
1 mg/kg/s.c 83.3%
2 mg/kg/s.c 100%