Table 2: Effect of diclofenac (10mg/kg/i.p.), retigabine (8mg/kg/i.p.), and their combination on mean latency period, frequency of convulsion, frequency of protection, and death rate in pilocarpine (350mg/kg/i.p.) induced SE in mice (model 2).


Group Parameter  Control group pilocarpine (N = 6)  Diclofenac group (N = 6)  Retigabine group (N = 6)  Combined group (N = 6)  P 


Latency period (min) Mean ± SE  9.4 ± 0.96 ^{ a }  10.37 ± 0.92 ^{ a }  30.50 ± 4.58 ^{ b }  41 ± 6.68 ^{ c }  $ <0.001** 
% of change  —–  10%  224%  336%  
Frequency of convulsion (%)  100% ^{ a }  100% ^{ a }  66.7% ^{ a }  50% ^{ b }  # 0.04* 
Frequency of protection (%)  0% ^{ a }  0% ^{ a }  33.3% ^{ a }  50% ^{ b }  
% of change  ——  0  33.3%  50%  
Death rate N (%)  83.3% ^{ a }  83.3% ^{ a }  66.7% ^{ a }  66.7% ^{ a }  # 0.83 NS 
% of change  ——  0  20%  20%  


Groups with the same letters are statistically insignificant (p > 0.05).  
^{*}significant (p < 0.05). $: ANOVA (F) test. #: Chisquare test. NS: nonsignificant.  
N = the number of animals in each group.  
• Mean latency period is the mean period (min) between injection of pilocarpine and onset of convulsion.  
• Frequency of convulsion is the number of convulsed animals on the total number of animals.  
• Frequency of protection is the number of nonconvulsed animals on the total number of animals. 