Table 2: Effect of diclofenac (10mg/kg/i.p.), retigabine (8mg/kg/i.p.), and their combination on mean latency period, frequency of convulsion, frequency of protection, and death rate in pilocarpine- (350mg/kg/i.p.) induced SE in mice (model 2).


Group Parameter Control group pilocarpine (N = 6) Diclofenac group (N = 6) Retigabine group (N = 6) Combined group (N = 6) P

Latency period (min) Mean ± SE 9.4 ± 0.96 a 10.37 ± 0.92 a 30.50 ± 4.58 b 41 ± 6.68 c $ <0.001**
% of change —– 10% 224% 336%
Frequency of convulsion (%) 100% a 100% a 66.7% a 50% b # 0.04*
Frequency of protection (%) 0% a 0% a 33.3% a 50% b
% of change —— 0 33.3% 50%
Death rate N (%) 83.3% a 83.3% a 66.7% a 66.7% a # 0.83 NS
% of change —— 0 20% 20%

Groups with the same letters are statistically insignificant (p > 0.05).
*significant (p < 0.05). $: ANOVA (F) test. #: Chi-square test. NS: non-significant.
N = the number of animals in each group.
• Mean latency period is the mean period (min) between injection of pilocarpine and onset of convulsion.
• Frequency of convulsion is the number of convulsed animals on the total number of animals.
• Frequency of protection is the number of non-convulsed animals on the total number of animals.