Figure 4: Effect of venlafaxine and/or cysteamine on anxiety behavior in CORT-induced anxiety/depression mouse model. Open Field test: Frequency of travels to center (a) and duration (sec) spent by the mice in the center zone (b). Light-Dark Box test: Duration (sec) spent in light box (c). Elevated Plus Maze test: duration (sec) spent in open arms and center (d). Values are mean ± SE (n = 8), analyzed by one-way ANOVA followed by Dunnett's multiple comparisons post hoc test. *P < 0.05 versus vehicle group, #P < 0.05 versus CORT group. OF: Open field, LDB: Light-Dark Box, EPM: Elevated plus maze, CORT: corticosterone, Ven low: Venlafaxine 10 mg/kg/day, Ven high: Venlafaxine 20 mg/kg/day, Cys: Cysteamine 150 mg/kg/day.