Table 2: Effects of irbesartan (IRB), pioglitazone (PIO), and their combination on renal blood flow (RBF) and lipid peroxidation (MDAp) in diabetic rats.


Parameters Groups Renal blood flow (ml/min.) Mean ± SE MDAp (µmol/ml) Mean ± SE

Control 11.4 ± 0.9 3.2 ± 0.31
DM group 2.3 ± 0.15 a 7.11 ± 0.31 a
Irbesartan-treated 6.5 ± 0.39 b 5.13 ± 0.19 b
Pioglitazone-treated 7.1 ± 0.45 b 5.6 ± 0.41 b
IRB+PIO high dose treated 9.9 ± 0.40 b c d 4.1 ± 0.29 b c d
IRB+PIO low dose treated 10.1 ± 0.46 b c d 4.51 ± 0.23 b c d

aSignificant difference from control group.
bSignificant difference from diabetic group.
cSignificant difference from irbesartan group.
dSignificant difference from pioglitazone group.