Figure 2: Effects of irbesartan and pioglitazone on histopathological changes in rats with diabetic
nephropathy. A) Cut section of normal renal tissue of control. B) Cut section of renal
diabetic nephropathy revealed diffuse diabetic glomerular sclerotic lesion, which
is characterized by diffuse thickening of glomerular capillary wall and a generalized
increase in mesangial matrix in all mesangial regions of all glomeruli. C) Cut section
of renal tissues of STZ induced diabetic nephropathy in rats treated with irbesartan
showing mild thickening of glomerular capillary wall and mild changes in mesangial
matrix (H & E x 40). D) Cut section of renal tissues of STZ induced diabetic nephropathy
in rats treated with pioglitazone showing mild thickening of glomerular capillary
wall and mild changes in mesangial matrix (H & E x 40). E) Cut section of renal tissues
of STZ induced diabetic nephropathy in rats treated with large doses of pioglitazone
(30mg/kg/day) + irbesartan (30mg/kg/day) showing mild thickening of glomerular capillary
wall and mild changes in mesangial matrix (H & E x 40). F) Cut section of renal tissues
of STZ induced diabetic nephropathy in rats treated with small doses of pioglitazone
(15mg/kg/day) + irbesartan (5mg/kg/day) showing mild thickening of glomerular capillary
wall and mild changes in mesangial matrix (H & E x 40).
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