Figure 8: Allosteric network in AR antagonism. A) AR-1881 complex (PDB 1E3G), showing how agonists (such as R1881) interact stably with W741. Dashed lines indicate the proposed movement of W741 and H874 in the absence of a stable interaction. B) Antagonist HFT is modeled in wildtype AR pocket. With no ligand interaction, Duan et al propose that W741 would swing over, pushing H874 to hydrogen bond with backbone of I899. This interaction disrupts the H12 conformation, in a proposed mechanism of antagonism [76].